You can buy Torinat at the lowest price in the online pharmacy Nextgen.ooo . Everolimus is a derivative of rapamycin (sirolimus) and works similarly to rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. Like other mTOR inhibitors, everolimus acts exclusively on the mTORC1 protein and not on the mTORC2 protein.
 
Everolimus is indicated for the treatment of postmenopausal women with advanced hormone receptor-positive, HER2-negative breast cancer (advanced HR+ BC) in combination with exemestane after failure of letrozole or anastrozole. Indicated for the treatment of adult patients with advanced pancreatic neuroendocrine tumors (PNETs) with unresectable, locally advanced, or metastatic disease. Indicated for the treatment of adult patients with advanced renal cell carcinoma (RCC) following failure of sunitinib or sorafenib. Indicated for the treatment of adult patients with renal angiomyolipoma and tuberous sclerosis complex (TSC) who do not require immediate surgical intervention. Indicated in pediatric and adult patients with tuberous sclerosis complex (TSC) for the treatment of subependymal giant cell astrocytoma (SEGA) that requires therapeutic intervention but cannot be cured.
 
Everolimus is an mTOR inhibitor that binds with high affinity to FK506-binding protein-12 (FKBP-12), thereby forming a drug complex that inhibits mTOR activation. This inhibition reduces the activity of downstream effectors, resulting in a block in the transition of cells from G1 to S phase and subsequently inducing cell growth arrest and apoptosis. Everolimus also inhibits the expression of hypoxia-inducible factor, which results in decreased expression of vascular endothelial growth factor. Everolimus inhibition of mTOR results in decreased cell proliferation, angiogenesis, and glucose uptake.