You can buy Hertab at the lowest price in the online pharmacy Nextgen.ooo . Lapatinib is an antineoplastic agent and tyrosine kinase inhibitor used to treat advanced or metastatic HER-negative breast cancer in patients who have previously received chemotherapy treatment.
 
Lapatinib is an anticancer drug developed by GlaxoSmithKline (GSK) for the treatment of solid tumors such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in combination with the chemotherapy drug capecitabine. Lapatinib is an inhibitor of the human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor 1 (HER1/EGFR/ERBB1) tyrosine kinases. It binds to the intracellular phosphorylation domain to prevent receptor autophosphorylation upon ligand binding.
 
Lapatinib inhibits ERBB-induced tumor cell growth in vitro and in various animal models. An additive effect was demonstrated in an in vitro study when lapatinib and 5-fluorouracil (the active metabolite of capecitabine) were used in combination in 4 tumor cell lines tested. Lapatinib retained significant activity against breast cancer cell lines selected for long-term growth in trastuzumab-containing medium in vitro. These in vitro data suggest no cross-resistance between the two agents.
Indicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress human epidermal receptor type 2 (HER2) protein and who have received prior therapy including an anthracycline, a taxane, and trastuzumab.