You can buy Decintas at the lowest price in the online pharmacy Nextgen.ooo . Decitabine is a chemotherapeutic pyrimidine nucleoside analogue used to treat myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding changes in gene expression.
 
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with different etiologies and manifestations, including neutropenia and thrombocytopenia. Further mutations leading to increased proliferation of cancer cells may eventually lead to secondary acute myeloid leukemia with a poor prognosis. Among the treatment options, nucleoside analogs such as decitabine and azacitidine integrate into cellular DNA and inhibit the action of DNA methyltransferases, resulting in therapeutic benefits associated with global hypomethylation.
Decitabine was approved by the FDA for the treatment of MDS on February 5, 2006. It is also available as an oral combination drug with the cytidine deaminase inhibitor cedazuridine.
 
Decitabine is considered a prodrug because it requires transport into cells and subsequent phosphorylation by various kinases to form the active molecule 5-aza-2'-deoxycytidine triphosphate, which is incorporated by DNA polymerase during DNA replication. Once incorporated into DNA, decitabine is recognized as a substrate by DNA methyltransferase (DNMT) enzymes, particularly DNMT1, but due to the presence of the N5 rather than C5 atom, traps DNMT via irreversible covalent bond formation. At low concentrations, this mode of action depletes DNMT and results in global DNA hypomethylation, while at high concentrations it additionally results in double-strand breaks and cell death.
 
The general hypothesis regarding the therapeutic efficacy of decitabine is that the global hypomethylation it induces results in the expression of previously silent tumor suppressor genes. However, there are other proposed mechanisms also associated with this alteration of DNA methylation, including indirect alteration of transcription through effects on transcription factors, indirect alteration of histone modifications and chromatin structure, and activation of pathways involved in the DNA damage response. The overall effect of decitabine is to reduce tumor cell proliferation and increase the expression of tumor suppressor genes.